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KMID : 0390119930330020247
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Journal of Pusan Medical College
1993 Volume.33 No. 2 p.247 ~ p.256
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Result in Treatment of Patients with uterine myoma with GnRH Agonists (Decapeptyl(r))
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Abstract
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GnRH agonists have been shown to be effective in reducing the volume of uterine leiomyomas. Some authors have suggested the preoperative use of these drugs with the aim of facilitating myomectomy and dcereasing postoperative morbidity in
conservative
and definitive surgery for myomas.
The author analysed the benefit of pre-operative GnRH agonist(Decapeptyl) treatment in forty-three women was done myomectomy or total abdominal hysterectomy. The aim of the study was to assess the effect of GnRH agonist for the preoperative
treatment of
uterine leiomyoma size, serum hormonal levels and side effect of them.
@ES The following results were obtained:
@EN 1. After the first injection, the regression in serum LH was very slower, not significantly and there was no significant regression in serum FSH.
2. Serum estradiol levels fell significantly 4 weeks after first injection (170.1±27.6 pg/ml to 40.3±20.6pg/ml) and after then, the mean value of serum estradiol was under 20 pg/ml till 16 weeks after first injection.
3. After the second injection, almost all patients became amenorrheic, and then resumption of menstruation occurred at 5 to 10 weeks after the myomectomy.
4. A significant reduction in uterine volume occurred at 4 weeks after first injection and maximum reduction occurred at 4 weeks after last injection.
5. There were potential advantages of GnRH agonist therapy before myomectomy such as: (1) easier and safer to isolate the myoma: (2) less intraoperative blood loss: (3) smaller myometrial defects.
6. Thirty-eight of forty-three patients experienced hot flush, It was the most common side effect of GnRH agonist therapy, and then vaginal dryness, headache, insomnia, dyspareunia were manifested. But these symptoms were disappeared with
resumption of
menstruation after the myomectomy.
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